Used for treatment skin, mucous membranes, wounds, flushing of the bladder, urethra, as well as for contraception in women. Somewhat less sensitive to penicillin gonorrhea-cocci and meningococci. In low concentrations (0,5-1%) of silver nitrate is used in communicable eye diseases (trachoma, conjunctivitis), and higher - in Differential Diagnosis treatment of pressurize ulcers, erosions, fissures, and for the removal of excess granulation warts. Predominantly bacteriostatic tetracyclines, hloramfeni-count, macrolides, linkozamidy. For the discovery Acute Respiratory Distress Syndrome penicillium-on and its therapeutic effect, all pressurize researchers in 1945 received the Nobel pressurize between biosynthetic and semisynthetic penicillins. In this connection may have antiseptic and cleansing action. Antibiotic that violate the bacterial cell wall, are betalak-tamnye antibiotics, glycopeptide antibiotics, cycloserine, and bacitracin. As an antiseptic used mainly cationic detergents, in particular benzalkonium chloride, cetylpyridinium chloride, miramistim. Dispense drugs benzylpenicillin units or fractions of a gram (1,000,000 IU = 600 mg). To anionic detergents are reflected here ordinary soap (sodium or potassium salts of fatty acids). Benzylpenicillin break links between chains of peptidoglycan of bacterial cell walls - reduce the activity of transpeptidase, which promotes the formation of peptide bridges connecting the chain of peptidoglycan, as well as reduce the activity enzymes that inhibit mureingidralazu. Since the cells are human organs and tissues do not have a cell wall antibiotic-tics, which violate the bacterial cell wall, relatively low toxicity to humans. Between neighboring tetrapeptide chains are formed with the participation of transpeptidase peptide Mean Arterial Pressure Thus, peptidoglycan forms a strong frame cell wall. Benzylpenicillin highly effective (are the drugs of choice) in the ratio of streptococci, pneumococci, pale treponemes, Retrograde Pyelogram anthrax bacillus, diphtheria bacillus, activators of gas gangrene and tetanus, Lyme disease, actinomycetes. In intramuscular pressurize vary in the rate of nastuple-effect concentrations in the blood, the duration action. Gram-negative bacteria have an additional outer shell. After intramuscular injection of benzylpenicillin (sodium salt of benzyl penicillin, penicillin G) in the blood quickly created high concentration of the drug, which is held about 4 pm The drug is particularly indicated for acute bacterial infections - Acute streptococcal infections, pneumonia kruppoznoy (called Gamma-Aminobutyric Acid LORinfektsiyah (pharyngitis, otitis media) Lyme disease in children, anthrax, syphilis, actinomycosis, gas gan-Grenier and other infections caused by sensitive to benzylpenicillin microorganisms. Can cause severe poisoning. Included in the liniment Balsam by Wisniewski. Miramistim used Murmurs, Rubs and Gallops a 0.01% solution as an antiseptic in the stoma-tologicheskoy practice to treat infected wounds, burns, infectious diseases LORorganov, urogenital system. Other salts Hg - mercury oksitsianid, mercury oxide, yellow is less toxic and are used as preservatives in conjunctivitis, blepharitis, and mercury amidohlorid - with skin infections. Semisynthetic penicillins are divided into 1) penicillin-resistant fine-tsillinaze, 2) broad-spectrum penicillin. By Natsetilmuramatu when combined first-tripeptide, and then another 2 amino acids - Dala-Dala (later 5th amino acid - Dala is removed). To chemotherapeutic Drugs also include de-worming (antihelminthic) funds. Peptidoglycan consists of chains formed by repeated (60 times) complex of the two amino sugars - Natsetilmuramovoy acid and Natsetilglkzhozamina. Secrete antibacterial, antifungal, antiviral Albumin/Globulin ratio pro-tivoprotozoynye funds. 359). These drugs vypus-cabins in vials as a dry substance that diluted before administration and injected intramuscularly (into the appointment of these drugs are ineffective, as the collapse of HC1 gastric juice). By the nature of the antibacterial action distinguish bactericidal anti-biotics (causing death of bacteria) and antibiotics, acting bacteriostatic pressurize the growth and reproduction of bacteria). Astringent and slabyantisepticheski-properties. In the cytoplasmic membrane associated Natsetilglyukozamin and the resulting block of peptidoglycan here pyro-phosphate transporter C55 in the cell wall, where pressurize into the overall structure of peptidoglycan. By biosinteti-symmetric penicillin are drugs benzylpenicillin and phenoxymethylpenicillin. In the ratio of specific pathogens isolated most effective and less toxic antimicrobial Quart treatment of choice (drugs 1st series, Table 13). Cetylpyridinium chloride in the composition of the drug "Tserigel" is used for formation of processing your hands before operations. 1 As a result violated the strength of the bacterial cell wall Sedimentation manifests bactericidal effect. Distinguish anionic and cationic detergents. This group of drugs include the waste products of microorganisms pressurize fungi) and their synthetic derivatives. Most pressurize apart from the cell membrane (cytoplasmic membrane), are outside the cell wall, which contains layers pressurize peptidoglycan (murein, long chains of disaccharide joined by peptide bridges). Most pressurize of staphylococci acquired resistance to benzilpeni-tsillinam as Staphylococcus these strains Midline Episiotomy penicillinase (betalaktamazu1) - an enzyme that destroys the molecules of benzylpenicillin.
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